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Results for "

antibiotic ionophore

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (21) Apoptosis (12) Autophagy (8) Bacterial (20) Calcium Channel (2) Fungal (6) HIF/HIF Prolyl-Hydroxylase (1) Influenza Virus (1) Mitochondrial Metabolism (1) Mitophagy (1) Na+/H+ Exchanger (NHE) (2) NOD-like Receptor (NLR) (2) Oxidative Phosphorylation (5) Parasite (8) PKC (2) Potassium Channel (2) Pyroptosis (1) Sodium Channel (1) Wnt (6) β-catenin (4)
By Research Areas:	Cancer (17) Infection (20) Neurological Disease (1)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Antibiotic

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B1071

Lasalocid 2 Publications Verification Lasalocid-A; ionophore X-537A; antibiotic X-537A	Bacterial Autophagy Antibiotic Parasite	Infection Cancer
Lasalocid (Lasalocid-A; Ionophore X-537A; Antibiotic X-537A) is an antibacterial agent and a coccidiostat, used in the feed additives

HY-13434

Ionomycin 45+ Cited Publications SQ23377	Calcium Channel PKC Bacterial Apoptosis Antibiotic	Infection Cancer
Ionomycin (SQ23377) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin (SQ23377) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin also induces the activation of protein kinase C (PKC) .

HY-13434A

Ionomycin calcium 45+ Cited Publications SQ23377 calcium	Calcium Channel PKC Bacterial Apoptosis Antibiotic	Infection Cancer
Ionomycin calcium (SQ23377 calcium) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin calcium (SQ23377 calcium) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin calcium (SQ23377 calcium) also induces the activation of protein kinase C (PKC) .

HY-15597

Salinomycin 20+ Cited Publications Procoxacin	Bacterial Wnt β-catenin Mitophagy Autophagy Apoptosis Antibiotic Parasite	Cancer
Salinomycin (Procoxacin), a polyether potassium ionophore antibiotic, selectively inhibits the growth of gram-positive bacteria. Salinomycin is a potent inhibitor of Wnt/β-catenin signaling, blocks Wnt-induced LRP6 phosphorylation. Salinomycin (Procoxacin) shows selective activity against human cancer stem cells .

HY-121333

Dinactin	Antibiotic Wnt β-catenin	Infection Neurological Disease Cancer
Dinactin, an *antibiotic* ionophore produced by Streptomyces species, as an effective small molecule targeting Wnt/β-catenin signaling pathway in cancer cells. Dinactin shows marked inhibition of HCT-116 cell growth with an IC₅₀ of 1.1 µM. Dinactin shows anti-proliferative activity against the cancer cells in apoptosis-independent manner. Dinactin is also an effective agent for the research of neuropathic pain .

HY-B1071A

Lasalocid sodium 2 Publications Verification Lasalocid-A sodium; ionophore X-537A sodium; antibiotic X-537A sodium	Bacterial Autophagy Antibiotic Parasite	Infection Cancer
Lasalocid sodium (Lasalocid-A sodium) treatment led to an increase in cell wall thickness, whilst the quantity and sugar composition of the cell wall remained unchanged in BY-2 cells.

HY-B1327

Chlortetracycline hydrochloride 3 Publications Verification 7-Chlorotetracycline hydrochloride	Bacterial Antibiotic Parasite	Infection
Chlortetracycline hydrochloride (7-Chlorotetracycline hydrochloride) is a specific and potent calcium ionophore antibiotic, inhibits binding of aminoacyl-tRNA to ribosomes.

HY-B1327A

Chlortetracycline 7-Chlorotetracycline	Bacterial Antibiotic Parasite	Infection
Chlorotetracycline (7-Chlorotetracycline) is a specific and potent calcium ionophore antibiotic, inhibits binding of aminoacyl-tRNA to ribosomes.

HY-100381

Nigericin sodium salt Maximum Cited Publications 98 Publications Verification	Potassium Channel NOD-like Receptor (NLR) Bacterial Antibiotic	Infection Cancer
Nigericin sodium salt is an antibiotic from Streptomyces hygroscopicus that works by acting as an H ⁺, K ⁺, and Pb ²⁺ ionophore, a NLRP3 activator .

HY-111525

Monactin	Oxidative Phosphorylation Bacterial Antibiotic	Infection
Monactin is a mactrotetralide antibiotic and a non-selective ionophore for monovalent cations, including potassium, sodium, and lithium. Monactin is isolated from Streptomyces and has antiproliferative activity .

HY-B1327S

Chlortetracycline-d6 hydrochloride 7-Chlorotetracycline-d₆ hydrochloride	Bacterial Antibiotic	Infection
Chlortetracycline-d₆ (hydrochloride) is the deuterium labeled Chlortetracycline hydrochloride. Chlortetracycline hydrochloride (7-Chlorotetracycline hydrochloride) is a specific and potent calcium ionophore antibiotic, inhibits binding of aminoacyl-tRNA to ribosomes.

HY-P2324

Gramicidin A 1 Publications Verification	Bacterial HIF/HIF Prolyl-Hydroxylase Antibiotic	Infection Cancer
Gramicidin A is a peptide component of gramicidin, an *antibiotic* mixture originally isolated from B. brevis. Gramicidin A is a highly hydrophobic channel-forming ionophore that forms channels in model membranes that are permeable to monovalent cations. Gramicidin A induces degradation of hypoxia inducible factor 1 α (HIF-1α) .

HY-17439

Salinomycin sodium salt 20+ Cited Publications Salinomycin sodium; Sodium salinomycin	Wnt β-catenin Bacterial Autophagy Apoptosis Antibiotic Parasite	Cancer
Salinomycin sodium salt (Salinomycin sodium), an antibiotic potassium ionophore, is a potent inhibitor of Wnt/β-catenin signaling. Salinomycin sodium salt (Salinomycin sodium) acts on the Wnt/Fzd/LRP complex, blocks Wnt-induced LRP6 phosphorylation, and causes degradation of the LRP6 protein. Salinomycin sodium salt (Salinomycin sodium) shows selective activity against human cancer stem cells .

HY-N0150

Monensin sodium 15+ Cited Publications Monensin A sodium	Bacterial Antibiotic Na+/H+ Exchanger (NHE) Parasite Apoptosis Fungal Wnt	Infection Cancer
Monensin (Monensin A) sodium, an orally active *antibiotic, is an ionophore* that mediates Na ⁺/H ⁺ exchange. Monensin sodium is a potent Wnt signaling inhibitor. Monensin sodium causes a marked enlargement of the multivesicular bodies (MVBs) and regulates exosome secretion. Monensin sodium can be used for bacterial, fungal, and parasitic infections research, and shows anticancer effects .

HY-N4302

Monensin Monensin A	Bacterial Apoptosis Antibiotic Parasite Na+/H+ Exchanger (NHE) Fungal Wnt	Infection Cancer
Monensin (Monensin A), an orally active *antibiotic, is an ionophore* that mediates Na ⁺/H ⁺ exchange. Monensin is a potent Wnt signaling inhibitor. Monensin causes a marked enlargement of the multivesicular bodies (MVBs) and regulates exosome secretion. Monensin can be used for bacterial, fungal, and parasitic infections research, and shows anticancer effects .

HY-P2324A

Gramicidin A TFA	Antibiotic Bacterial	Infection
Gramicidin A (TFA) is a peptide component of gramicidin, an *antibiotic* mixture originally isolated from B. brevis. Gramicidin A (TFA) is a highly hydrophobic channel-forming ionophore that forms channels in model membranes that are permeable to monovalent cations. Gramicidin A (TFA) induces degradation of hypoxia inducible factor 1 α (HIF-1α) .

HY-N6790

Nonactin Ammonium ionophore I	Oxidative Phosphorylation Potassium Channel Mitochondrial Metabolism Bacterial Influenza Virus Apoptosis Antibiotic	Infection Cancer
Nonactin is a naturally occurring macrotetrolide antibiotic from Streptomyces griseus. Nonactin acts as an ionophore for monovalent cations, including K ⁺, and NH₄ ⁺ . Nonactin is able to uncouple the oxidative phosphorylation (OXPHOS) of mitochondria. Nonactin selectively induces apoptosis in cell lines harboring active mutant β-catenin . Nonactin inhibits the surface expression of endogenous HSP60 .

HY-N6693

Valinomycin 3 Publications Verification NSC 122023	Apoptosis Antibiotic Autophagy Fungal	Infection Others Cancer
Valinomycin is a potassium-specific ionophore, the valinomycin-K ⁺ complex can be incorporated into biological bilayer membranes with the hydrophobic surface of valinomycin, destroys the normal K ⁺ gradient across the membrane, and as a result kills the cells, incorporating into liposomes can significantly reduces the cytotoxicity and enhances the targeting effect. Valinomycin exhibits *antibiotic*, antifungal, antiviral, antitumor and insecticidal efficacy, thus can be used for relevant research .

HY-127019

Nigericin	Sodium Channel NOD-like Receptor (NLR) Bacterial Apoptosis Antibiotic Pyroptosis Wnt β-catenin	Infection Cancer
Nigericin is an *antibiotic* derived from Streptomyces hygroscopicus that act as a K ⁺/H ⁺ ionophore, promoting K ⁺/H ⁺ exchange across mitochondrial membranes. Nigericin shows promising anti-cancer activities through decreasing intracellular pH (pHi), and inactivation of Wnt/β-catenin signals. Nigericin induces pyroptosis through caspase 1/GSDMD in TNBC .

HY-N6687

Calcimycin 5+ Cited Publications A-23187; antibiotic A-23187	Oxidative Phosphorylation Bacterial Fungal Apoptosis Autophagy Antibiotic	Infection Cancer
Calcimycin (A-23187) is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin induces Ca ²⁺-dependent cell death by increasing intracellular calcium concentration. Calcimycin inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin induces apoptosis .

HY-N6687B

Calcimycin hemimagnesium A-23187 hemimagnesium; antibiotic A-23187 hemimagnesium	Oxidative Phosphorylation Bacterial Fungal Apoptosis Autophagy	Infection Cancer
Calcimycin (A-23187) hemimagnesium is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin hemimagnesium induces Ca ²⁺-dependent cell death by increasing intracellular calcium concentration. Calcimycin hemimagnesium inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin hemimagnesium also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin hemimagnesium induces apoptosis .

HY-N6687A

Calcimycin hemicalcium salt A-23187 hemicalcium salt; antibiotic A-23187 hemicalcium salt	Oxidative Phosphorylation Bacterial Fungal Apoptosis Autophagy Antibiotic	Infection Cancer
Calcimycin hemicalcium salt (A-23187 hemicalcium salt) is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin hemicalcium salt induces Ca ²⁺-dependent cell death by increasing intracellular calcium concentration. Calcimycin hemicalcium salt inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin hemicalcium salt also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin hemicalcium salt induces apoptosis .

Gramicidin A 1 Publications Verification	Bacterial HIF/HIF Prolyl-Hydroxylase Antibiotic	Infection Cancer
Gramicidin A is a peptide component of gramicidin, an *antibiotic* mixture originally isolated from B. brevis. Gramicidin A is a highly hydrophobic channel-forming ionophore that forms channels in model membranes that are permeable to monovalent cations. Gramicidin A induces degradation of hypoxia inducible factor 1 α (HIF-1α) .

Valinomycin 3 Publications Verification NSC 122023	Apoptosis Antibiotic Autophagy Fungal	Infection Others Cancer
Valinomycin is a potassium-specific ionophore, the valinomycin-K ⁺ complex can be incorporated into biological bilayer membranes with the hydrophobic surface of valinomycin, destroys the normal K ⁺ gradient across the membrane, and as a result kills the cells, incorporating into liposomes can significantly reduces the cytotoxicity and enhances the targeting effect. Valinomycin exhibits *antibiotic*, antifungal, antiviral, antitumor and insecticidal efficacy, thus can be used for relevant research .

Gramicidin A TFA	Antibiotic Bacterial	Infection
Gramicidin A (TFA) is a peptide component of gramicidin, an *antibiotic* mixture originally isolated from B. brevis. Gramicidin A (TFA) is a highly hydrophobic channel-forming ionophore that forms channels in model membranes that are permeable to monovalent cations. Gramicidin A (TFA) induces degradation of hypoxia inducible factor 1 α (HIF-1α) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B1071

Lasalocid 2 Publications Verification Lasalocid-A; ionophore X-537A; antibiotic X-537A	Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Disease Research Fields Cancer	Bacterial Autophagy Antibiotic Parasite
Lasalocid (Lasalocid-A; Ionophore X-537A; Antibiotic X-537A) is an antibacterial agent and a coccidiostat, used in the feed additives

HY-13434

Ionomycin 45+ Cited Publications SQ23377	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Disease Research Anticancer Disease Research Fields Other Antibiotics	Calcium Channel PKC Bacterial Apoptosis Antibiotic
Ionomycin (SQ23377) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin (SQ23377) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin also induces the activation of protein kinase C (PKC) .

HY-13434A

Ionomycin calcium 45+ Cited Publications SQ23377 calcium	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Disease Research Anticancer Disease Research Fields Other Antibiotics	Calcium Channel PKC Bacterial Apoptosis Antibiotic
Ionomycin calcium (SQ23377 calcium) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin calcium (SQ23377 calcium) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin calcium (SQ23377 calcium) also induces the activation of protein kinase C (PKC) .

HY-B1071A

Lasalocid sodium 2 Publications Verification Lasalocid-A sodium; ionophore X-537A sodium; antibiotic X-537A sodium	Infection Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Disease Research Fields	Bacterial Autophagy Antibiotic Parasite
Lasalocid sodium (Lasalocid-A sodium) treatment led to an increase in cell wall thickness, whilst the quantity and sugar composition of the cell wall remained unchanged in BY-2 cells.

HY-B1327

Chlortetracycline hydrochloride 3 Publications Verification 7-Chlorotetracycline hydrochloride	Structural Classification Classification of Application Fields Source classification Antibacterial Disease Research Other Antibiotics Plant agriculture research Infection Monophenols Microorganisms Antibiotics Resistance Selection Animal Husbandry Phenols Disease Research Fields	Bacterial Antibiotic Parasite
Chlortetracycline hydrochloride (7-Chlorotetracycline hydrochloride) is a specific and potent calcium ionophore antibiotic, inhibits binding of aminoacyl-tRNA to ribosomes.

HY-100381

Nigericin sodium salt Maximum Cited Publications 98 Publications Verification	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Disease Research Disease Research Fields Other Antibiotics Cancer	Potassium Channel NOD-like Receptor (NLR) Bacterial Antibiotic
Nigericin sodium salt is an antibiotic from Streptomyces hygroscopicus that works by acting as an H ⁺, K ⁺, and Pb ²⁺ ionophore, a NLRP3 activator .

HY-111525

Monactin	Infection Structural Classification Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Anticancer Disease Research Fields	Oxidative Phosphorylation Bacterial Antibiotic
Monactin is a mactrotetralide antibiotic and a non-selective ionophore for monovalent cations, including potassium, sodium, and lithium. Monactin is isolated from Streptomyces and has antiproliferative activity .

HY-N0150

Monensin sodium 15+ Cited Publications Monensin A sodium	Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Disease Research Fields Other Antibiotics Plant agriculture research Cancer	Bacterial Antibiotic Na+/H+ Exchanger (NHE) Parasite Apoptosis Fungal Wnt
Monensin (Monensin A) sodium, an orally active *antibiotic, is an ionophore* that mediates Na ⁺/H ⁺ exchange. Monensin sodium is a potent Wnt signaling inhibitor. Monensin sodium causes a marked enlargement of the multivesicular bodies (MVBs) and regulates exosome secretion. Monensin sodium can be used for bacterial, fungal, and parasitic infections research, and shows anticancer effects .

HY-N4302

Monensin Monensin A	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields	Bacterial Apoptosis Antibiotic Parasite Na+/H+ Exchanger (NHE) Fungal Wnt
Monensin (Monensin A), an orally active *antibiotic, is an ionophore* that mediates Na ⁺/H ⁺ exchange. Monensin is a potent Wnt signaling inhibitor. Monensin causes a marked enlargement of the multivesicular bodies (MVBs) and regulates exosome secretion. Monensin can be used for bacterial, fungal, and parasitic infections research, and shows anticancer effects .

HY-N6790

Nonactin Ammonium ionophore I	Infection Structural Classification Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Disease Research Anticancer Disease Research Fields	Oxidative Phosphorylation Potassium Channel Mitochondrial Metabolism Bacterial Influenza Virus Apoptosis Antibiotic
Nonactin is a naturally occurring macrotetrolide antibiotic from Streptomyces griseus. Nonactin acts as an ionophore for monovalent cations, including K ⁺, and NH₄ ⁺ . Nonactin is able to uncouple the oxidative phosphorylation (OXPHOS) of mitochondria. Nonactin selectively induces apoptosis in cell lines harboring active mutant β-catenin . Nonactin inhibits the surface expression of endogenous HSP60 .

HY-N6693

Valinomycin 3 Publications Verification NSC 122023	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Disease Research Anticancer Disease Research Fields Other Antibiotics	Apoptosis Antibiotic Autophagy Fungal
Valinomycin is a potassium-specific ionophore, the valinomycin-K ⁺ complex can be incorporated into biological bilayer membranes with the hydrophobic surface of valinomycin, destroys the normal K ⁺ gradient across the membrane, and as a result kills the cells, incorporating into liposomes can significantly reduces the cytotoxicity and enhances the targeting effect. Valinomycin exhibits *antibiotic*, antifungal, antiviral, antitumor and insecticidal efficacy, thus can be used for relevant research .

HY-N6687

Calcimycin 5+ Cited Publications A-23187; antibiotic A-23187	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Disease Research Fields Polyether Antibiotics	Oxidative Phosphorylation Bacterial Fungal Apoptosis Autophagy Antibiotic
Calcimycin (A-23187) is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin induces Ca ²⁺-dependent cell death by increasing intracellular calcium concentration. Calcimycin inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin induces apoptosis .

HY-N6687A

Calcimycin hemicalcium salt A-23187 hemicalcium salt; antibiotic A-23187 hemicalcium salt	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Disease Research Fields Polyether Antibiotics	Oxidative Phosphorylation Bacterial Fungal Apoptosis Autophagy Antibiotic
Calcimycin hemicalcium salt (A-23187 hemicalcium salt) is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin hemicalcium salt induces Ca ²⁺-dependent cell death by increasing intracellular calcium concentration. Calcimycin hemicalcium salt inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin hemicalcium salt also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin hemicalcium salt induces apoptosis .

Cat. No.	Product Name	Chemical Structure

HY-B1327S

Chlortetracycline-d6 hydrochloride
Chlortetracycline-d₆ (hydrochloride) is the deuterium labeled Chlortetracycline hydrochloride. Chlortetracycline hydrochloride (7-Chlorotetracycline hydrochloride) is a specific and potent calcium ionophore antibiotic, inhibits binding of aminoacyl-tRNA to ribosomes.

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antibiotic ionophore

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Isotope-Labeled Compounds

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